Abstract

Incidence of Ulcerative Colitis (UC) and Crohn��?s Disease in Thyroid Disorders

Author(s):Nadeem Naeem, Imran Arshad, Shair Zaman and Zakirullah Khan

Aim: In patients with ulcerative colitis (UC) and Crohn’s disease (CD), an increase in thyroid dysfunction has been reported compared to normal people. This study was held to assess the thyroid disease prevalence in the inflammatory bowel disease patients group. Study Design: A retrospective study. Place and Duration: In the Medicine Department of Isra University Hospital, Hyderabad for one-year duration from March 2018 to March 2019. Methods: Total of 155 patients were included (120 UC, 35 CDs) and 63 healthy control subjects. Patients with free T3 (FT3), T4 (FT4), anti-TPO serum and TSH were evaluated retrospectively and with the group of control were compared. These patients were examined using nuclear imaging (scintigraphy) and thyroid ultrasound. Results: 42.9 ± 12.4 years was the average age of patients with IBD (76 women). The control group consisted of 42 women and 40.9 ± 12.1 years was the average age. In 18 patients (9.5%, 8 women, 6 men) out of 155 patients with inflammatory bowel disease, thyroid disease was diagnosed. The thyroid disorders frequency was higher in IBD group than in the group of control (18/155 vs. 1/63, p=0.042). There was no substantial dissimilarity in the frequency of thyroid orders in cases of CD and UC (5/40 vs. 13/115, p=0.912). In 4 (2.7%) IBD patients, Hashimoto’s thyroiditis were noted. Conclusion: According to many studies issued in the literature, we have noted a greater fraction of thyroid disease in inflammatory bowel disease patients. 

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