Abstract

Inflammatory Parameters in COVID-19: A Retrospective Study in a Tertiary Care Centre in Eastern India

Author(s):Jayati Gupta, Priyanka Maity, Dipanwita Nag and Himadri Mondal

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the recent pandemic of coronavirus disease 2019 (COVID-19). Inflammatory responses play a critical role in the progression of COVID-19. It is important to identify early manifestations of COVID-19 patients who are at risk for disease progression and manage them accordingly. In this study, we aimed to determine the inflammatory markers viz. C-reactive protein (CRP), D-dimer, procalcitonin, ferritin, and IL-6, in COVID-19 patients and compare these parameters between discharged (after recovery) and expired patients. We also looked for any association between these parameters and the number of days of hospitalization of the discharged (after recovery) patients. Methods: We conducted a retrospective observational study on 50 COVID-19 patients. The level of inflammatory markers viz. CRP, D-dimer, Procalcitonin, Ferritin, and IL-6 of the patients were recorded. The patients were divided into two broad categories: - Group A: Discharged from hospital after recovery; Group B: expired at hospital. Group A was divided into Group A1: Discharged from hospital after recovery, number of days of hospitalization ≤ 10; Group A2: Discharged from hospital after recovery, number of days of hospitalization>10. Results: Patients in group B (nonsurvivors) had significantly higher serum levels of D-dimer, procalcitonin, and ferritin than group A (survivors). Conclusions: High serum levels of D-dimer, procalcitonin, and ferritin can predict worse outcomes in COVID- 19 patients.

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