The current study was an attempt to explore the effect of palliative care on the satisfaction of patients with cancer who referred to Imam Reza Clinic-Seyedoshohada Hospital and Entekhab Center in Isfahan in 2014. A quasiexperimental research design was employed to pursue this clinical trial type of study. The population was comprised of all the patients suffering from cancer who also referred to Seyedoshohada Health Center (Palliative Care Center of Imam Reza (AS) and Entekhab Cancer Control Center) in Isfahan within the second 3 months of 2014. Of these, 60 patients were selected through convenient sampling as the research sample. The instruments adopted include: FAMCARE-P16 questionnaire to assess patient satisfaction with palliative care and Patient Information Form. The gathered data were then analyzed using distribution tables and analytical data analysis was also conducted using dependent samples t-test. The findings revealed the patient care mean score within the first (SD=7.36) and fourth weeks (SD=65.83) was 49.6 and 65.83, respectively which demonstrates a 14.37 rate of increase. This increase with t = -17.46 is to be statistically significant (p<0.01). Therefore, it could be concluded that palliative care is effective in the satisfaction of patients with cancer. According to the results obtained, it could be stated that palliative care is effective in the satisfaction of patients with cancer and leads to an increased level of satisfaction of patients suffering from cancer. And this method can be used to help improve patient's condition.