Introduction: Female-headed households are among the most vulnerable groups of society and there are potential of many critical jeopardies for these families. Therefore, this study was focused to evaluate the effect of home care program on self-efficacy of female-headed single parent households supported by Isfahan Behzisti-Welfare Organization in year 2015. Methodology: This study was a quasi-experimental design research with random selection of 36 female headed single parent. Prior to the nursing intervention, demographic and life style information of these families were evaluated using 70 questions in a questionnaires. In addition, a pre-test using a standard self-efficacy questionnaires with 17 questions were used to assess the level of self-efficacy of these families. Following the experiment, these families responded to the self-efficacy questionnaires. For descriptive statistics analysis, frequency, average, and standard deviation were evaluated. Furthermore, paired-sample t-test, Pearson's chi-squared test, Mann–Whitney test, Spearman's rank-order correlation, and Kruskal–Wallis one-way analysis of variance were analyzed using SPSS v.18 software for statistical inference analysis. Results: Our analysis revealed that there was a significant difference (p<0.05) between the score average of pre- and post- home care program. It supported our hypothesis that the supportive home care program had significant effect on self-efficacy of femaleheaded single parent households. Discussion and Conclusion: Following the effect of the supportive nursing intervention on self-efficacy of female-headed households, it should be mentioned that this supportive program can be the best strategic plan to increase the family’s health and preventing health issues. Therefore, given the multiple roles of public health nurse, supportive home care program is critical and should be emphasized.