After the growth of information technology, the traditional methods of teaching that are currently running do not alone meet the educational needs. Therefore, this research was conducted to investigate the effectiveness of using mobile educational software in increase of the amount of learning of dentistry students. In this semi-experimental study (pre-test and post-test), from between the last two years students of academic year 2015-16 of dentistry of Ahvaz Jundishapur University of Medical Sciences (AJUMS), 60 people were selected in a simple random way and divided randomly into two groups of intervention and control. Then the intervention group was given mobile educational software of the unit dental considerations on systemic patients; 30 days later, it was taken separate tests and their scores were compared with those of the control group who did not use software. The data were analyzed by SPSS V21 and regression test. The mean scores of awareness had increased in students of the intervention group before and after receiving the software and it was significant (P<0.05). Furthermore, the difference of the mean scores of awareness after the intervention between control group and intervention one had been significant (P<0.05). Based on the regression test, the age, gender, and semester had no impact on the score changes before and after the intervention. Although the use of smartphones was not included still in the formal curriculum of universities and educational institutions in line with the educational goals, but it allows students to use more various methods for learning.