Ischemic stroke is one of the major causes of death and disability, but predictive parameters such as CPR in this disease are not yet clear. The objective of this study was to investigate the relationship between serum levels of CRP and different types of CVA and its severity. In this case-control study, 161 patients with stroke (ischemic and hemorrhagic) were included. Stroke severity was measured based on NIHSS modified on admission and CRP was measured on admission (first 48 hours) and four days later. Then, T test and chi-square tests were used to compare the studied variables among various groups. The results showed that the highest and lowest CRP 48 hours after admission were seen respectively in severe stroke groups (22.56), minor ischemic (10.7), and hemorrhagic group (10.08) and the difference was statistically significant (P<0.001). Four days later, considering the CRP levels, the highest and lowest values were seen respectively in severe stroke (73) and mild (9.25) groups, which this difference was significant. In addition, significant difference (P<0.001) was seen between three severe, moderate and mild groups in terms of CRP rate (P<0.001). Studied groups characteristics including severity of CVA (severe, moderate, mild and hemorrhagic), age of patients, blood platelets, TG and CRP rate at first 48 hours and four days after admission to hospital were effective in MNIHSS amount of patients (P<0.05) .The results of this study indicated that the level of CRP on admission and four days after the admission of patients with stroke is closely correlated with ischemic stroke severity so that increasing severity of stroke causes an increase in level of CRP.