Self - esteem is an important factor for helping persons deal with life stressors. It is an important determinant of psychological well-being that is particularly problematic during an adolescent life stage. Low selfesteem might contribute to depression through both interpersonal and intrapersonal pathways. Many theories of depression postulate that low self esteem is a defining feature of depression.Aims: Self-esteem in adolescents has been associated with a number of risk and protective factors in previous studies. This study examined the relationship between low self esteem and depression among adolescents.Methods: This study used a case control (retrospective) design. Samples of 1120 adolescents, aged 14-17 years were selected for the study. Screening was done by using MINI-KID and the level of depression was assessed by using Beck depression inventory. Self esteem was measured by Rosenberg self esteem scale. Odds Ratio and Multivariate logistic regression were used to examine the relation between self-esteem and socio-demographic variables.Results: The odds ratio analysis revealed that adolescents who had low self esteem found to have 3.7 times (95% CI=1.9-6.9 and p- value 0.001) more risk of developing depression than the adolescents who had high self esteem.Conclusions: The findings implied that low self-esteem is a risk factor for depression among adolescents. Adolescents with low self esteem have to be identified earlier and prompt interventions will prevent future psychiatric illnesses. As an intervention towards the educational component pamphlet was distributed to the adolescents, parents and teachers.A concept programme called “Self Esteem Education & Development – SEED”programme, is planned for, from High school level.