Introduction: Breast cancer is the most common of all cancers worldwide. It is rare among men of all ages and women less than 30 years. Incidence rates increase over a lifetime, slowing down around menopause. National Cancer Institute (NCI) in Egypt reported that breast cancer represents 35.1% of all female cancers. Both Diabetes and breast cancer are common chronic diseases in women. Nearly 16% of breast cancer patients have diabetes.
Aim: This study was aiming to assess the level of CD44 and ILGF 1 in female patients with breast cancer with and without type II diabetes mellitus.
Patients and Methods: 53 Egyptian females with breast cancer had attended Minia Oncology Center. They were classified into 2 groups according to the presence of diabetes. Tissue CD44 and Tissue IGF-1 receptors expression, Estrogen Receptors, Progesterone Receptors expression were all estimated.
Results: Egyptian females with breast cancer and diabetes had significantly higher IGF-1R and higher CD44 Expression and lower ER and PR Expression in malignant.
Conclusion: The presence of diabetes mellitus may be an important contributor to breast cancer risk among Egyptian females. Both IGF-1R and/or CD44 over-expression associated with poor clinicpathological outcomes of breast cancers among diabetic females.
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