Background: Breast cancer screening programs may lead to a reduction of the cancer mortality rates among women. In this study, knowledge, and attitude towards mammography and Ultrasound (U/S) were evaluated among females living in the Taif region, Saudi Arabia. This examination was carried out using a well-structured electronic questionnaire from April to August 2020. A total number of 218 female applicants, aged in the range from 18 to 65 years old, participated in this investigation. Results: The obtained data led to the following conclusions 183 (83.95%) applicants had appropriate knowledge about mammography and U/S breast cancer screening tools and 86 (40.3%) advanced their knowledge levels through the use of social media. There was a significant correlation between good knowledge and the educational level of the participants (p=0.003). Regarding attitude and practices, 73.39% of the respondents have not had mammography or U/S experiences. Despite their good knowledge level, they justified their lack of experience through the following reasons: 59.5% did not have lump or pain, 14.19% were afraid of the results, and 11.49% were ashamed or afraid to perform it. Conclusion: This study implied insufficient attitude of women about mammography and ultrasound. Accordingly, relevant educational programs are required to improve the practices of women towards breast cancer.