Objectives: This study was aimed to measure and evaluate the morphological changes of the mandible, related to age and gender in partially edentulous and completely dentate subjects using panoramic radiographs. Methods: This study included a sample of 150 partially edentulous patients and 150 completely dentate patients enrolled in the College of Dentistry, King Saud Bin Abdulaziz University for Health Sciences between January 2015 and December 2018. Five mandibular morphological and anatomical parameters were measured using a Romexis software including; Condylar height. Gonial Angle, Ramus height, Antegonial notch depth and Ramal notch depth. Results: There was a significant difference (p=0.00) seen in the mean values of GA when comparing the partially edentulous (130.01 ± 7.79°) and completely dentate group (126.95 ± 6.64°). The mean values of GA were significantly larger among the younger age group (20-40) in both partially edentulous patients (131.58 ± 8.27°) and completely dentate group (127.17 ± 6.9°) (p<0.05). Conclusion: There was no relationship between the changes in the morphological measurements related to age and gender except for GA where younger subjects have higher GA values. Also, the mean values of GA were significantly higher in the partially edentulous group compared to completely dentate.