Introduction: Porcelain laminate veneer is considered a successful restoration if it is managed to survive in the oral cavity which depends on its sealing ability. Aim: To investigate and evaluate the cervical microleakage of porcelain veneers restorations fabricated from 2 types of CAD/CAM ceramic laminate bonded to teeth with different class V cavity filling material. Materials and Methods: Total 48 sounds, crack-free human upper first premolar extracted for orthodontic causes were selected for this study. Teeth were divided randomly into 2 study groups and further subdivided into 3 subgroups (8 samples each). Results: The statistical analysis have shown that the type of ceramic restoration and the composite filling had a highly significant effect on cervical microleakage and the interaction between the main factors was also highly significant. The results showed that the lowest mean of cervical microleakage sum was recorded for Group B3 (1056.279 ± SD) which is considered statistically significant compared to Group B1 (1495.030 ± SD) and Group B2 (1546.446 ± SD) and statistically highly significant compared to Group A1 (3180.705 ± SD), Group A3 (1837.429 ± SD) while Group A2 recorded the highest mean of microleakage sum (3210.037 ± SD). Conclusion: The type of ceramic restoration and the type of class V composite filling both had highly significant effects on the cervical microleakage mean. Cerec CPC veneers had significantly lower microleakage mean as compared to IPS e.max CAD veneers. The type of class V composite filling within 0.5 from the cervical finishing line of porcelain veneers that was filled with different composite filling had significantly higher microleakage mean compared to groups filled with the luting resin cement only.