Comatose patients deal with numerous moral challenges at ICU. The nurses have a significant role in recognizing these challenges and the approach to deal with them. Thus, the present study aims at clarifying nurses’ lived experience for dealing with the moral challenges in caring for comatose patients. This qualitative study was done applying a phenomenological approach at Kurdistan University of Medical Sciences from 2014 to 2015. Having done a purposeful sampling 10-experienced nurse was selected. The data was collected using 14 semi-structured indepth interviews. Data collection was continued to achieve a rich interpretation of the content and themes saturation. Data analysis was done applying Van Manen’s six-step method. In data analysis, 5 main themes were driven from the nurses’ experiences. These themes include resistance-focused flexibility, counselling guidelines, supportive participation, professional caring, and moral caring. The themes driven from the present study can be applied by hospital managers in dealing with moral challenges in caring for comatose patients. These themes are effective and helpful strategies for turning threats into opportunities in taking care of comatose patients.