Introduction: Many factors of tooth loss will compromise chewing and general health and quality of life. Saudi populations demonstrate a high prevalence of caries and a striking increase in dmft/DMFT. Usually, tooth loss is rehabilitated by different prosthetic options including implant, fixed partial denture and removable partial denture. Aim: To evaluate the relation of oral health-related quality of life with the type of prosthesis and oral health status among patients who have removable or fixed partial dentures in King Saud bin Abdulaziz University for health science, college of dentistry. Material and methods: Cross-sectional study would be conducted at the College of Dentistry, King Saud bin Abdulaziz University (KSAUHS) and Dental Centre, KAMC, NGHA. Convenient sampling was carried out by selecting 109 patients from those who visited the dental clinic. Oral health status was captured using the DMFT index. The collected data were entered and analyzed by adapting the SPSS computer software. Result: The type and quality of prosthesis and its effect on the OHRQoL on patients showed no significant relation (p=0.459), but the duration of wearing of prosthesis showed significant relation (p=0.046). Regarding DMF total of (n=109), 61 had low DMF, 48 had high DMF witch was statically significant (p=0.02). Conclusion: At the end of this study we conclude that there were no significant impacts on quality of life in relation to the type of prosthesis. On the other hand, we found a significant relation with OHRQoL in function domain, esthetic part and oral health status.