Orexin A and orexin B are neuropeptides that control appetite and play an important role in energy homeostasis. Central precocious puberty (CPP) is an energy consuming process, which characterized as GnRH neurons activated in advance. Kisspeptin is a trigger of GnRH neurons activation, known as a milestone of puberty initiating. Maternally expressed gene 3 (MEG3) is an imprinted long non-coding RNAs (LncRNAs), which is highly expressed in the brain and pituitary gland, may involve in pituitary hyperplasia of CPP. In this review, we searched literature to clarify the possible relationship between orexin A and CPP.