It was well documented that the physical activity level has a strong impact on individuals’ better quality of life. In Saudi Arabia, there is a lack of data regarding the positive association of physical activity, health-related quality of life among the Saudi population. Thus, the objective of this review was to highlight the perception of physical activities among adults with an especial focus among Saudi civilian in view of the existing literature. However, even in the lack of consistent physical activities and a weight-loss diet, relatively little expanses of repetitive exercise within an ordinary lifestyle, slightly rises in fitness, and less body fatness are linked with a better health-related quality of life and mood. In Saudi Arabia, little is known about the health benefits and the factors that motivate physical activity among Saudi adults. Thus more evidence is needed to show the perception of physical activity or exercise on quality of life particularly among Saudi population in light of the existent literature.