Physiological and Inflammatory Markers Alteration in Obesity-Related Iron Deficiency in Adults | Abstract

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)


Physiological and Inflammatory Markers Alteration in Obesity-Related Iron Deficiency in Adults

Author(s):Brwa Zahir, Kaniaw R. Khafar* and Mariwan A. Hama Salih

Homeostasis of iron, an essential micronutrient, is crucial to many physiological functions in the human body, such as cellular activity, erythropoiesis, and innate immunological response. So Iron deficiency anemia may occur from obesity's ability to disturb iron homeostasis. Increased hepcidin levels caused by chronic inflammation may be the cause of the link between obesity and iron insufficiency. This study aimed to investigate the associations between iron parameters, hepcidin, and inflammation markers in obese adults. For this cause, this current experiment is designed to investigate the iron profile and some hematological and inflammatory parameters in adults in Kurdistan region-Iraq. The cross-sectional study was designed within the setting of a medium private laboratory with participants being common people involved, two hundred adults were participated in this study and allocated into two groups according to BMI (control group (BMI ≤ 29.9): N=100 and obese group (BMI >30): N=100). Oxygen saturation (SpO2) and pulse rate were assessed. Blood sera (once) was obtained for iron profiles (s. Iron, Ferritin, Hepcidin) and inflammatory levels (C-Reactive Protein (CRP), Interleukin 6 (IL-6)). Our findings highlighted that all inflammatory markers increased significantly in the obese groups in both sexes and positive correlation with BMI with a significant decrease of iron in the obese group. This research reveals that hepcidin levels in adult obese people contribute to the development of iron deficiency anemia due to increased inflammation because obesity and visceral adiposity are positively correlated with higher cytokine levels, lowering these risk factors is crucial for preventing cytokine level increases.

Select your language of interest to view the total content in your interested language

Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology