Platelets have a major role to play in cessation of bleeding and hemostasis and the studies in the recent past have led to a better understanding in identifying their functions in regulation of immune response, wound healing, osteogenesis, and angiogenesis and is a subject of great interest. It has been proved that plalelets play a crucial role in the formation of blood clot and release growth factors, thereby promoting and maintaining the process of wound healing. Platelet rich fibrin (PRF) is product derived of platelets from one’s blood and when used either in its gel or liquid form, it enhances tissue repair. In the recent past, the PRF has been used extensively in various oral and maxillofacial surgical procedures successfully. We conducted a narrative review over the literature using electronic databases as; PUBMED, SCOPUS, Google Scholar studies involving data on platelet rich fibrin and its application in Oral and Maxillofacial Surgery. We reviewed the reference lists of included studies to find more relevant articles for additional evidence. It has been observed that PRF enhances the recovery and contributes to the post-operative healing and general well-being.