Previous studies have confirmed that some diseases are influenced by stress. Such diseases are diseases in which inflammations are the main aspects of them. One of the most common diseases that can be affected by stress is cold. The purpose of this study was to investigate the relationship between stress, anxiety and depression and the peoples’ cold over the years among women heads of households covered by Tehran Welfare. This study is a descriptive and correlational. The sample in this study included all female-headed family covered by Tehran Welfare, which is approximately 500 people according to the Welfare Organization statistics. According to Moran Table, 267 women heads of household were selected as research sample. The DASS-42 questionnaire was used to collect research data. The results showed that stress, depression and anxiety are positively associated with the common cold (P<0.01).Anxiety has also the ability to predict various colds. Results of the present study in line with foreign studies show that stress, depression and anxiety can lead to frequent colds and anxiety can predict recurrent colds in female-headed households covered by Tehran Welfare.