Objective: Favorable outcome of kidney transplantation is particularly expected in the case of living donation. The satisfactory result can be referred to as immediate graft function, defined by the fast postoperative recovery of renal function with satisfactory diuresis and no further need for dialysis. Methods: Prospective analysis of 40 living-donor renal transplants was performed to assess whether there is any predictive factor of immediate graft function. Patients were compared in two groups in accordance with their initial graft function (immediate vs. slow or delayed). Clinical data relevant to the recipients, their donors and harvested organs (kidney weight and dimension) were assessed. Results: No statistically significant differences were found between the groups. Conclusions: Further long-sampled studies are required to investigate the predictors of successful outcome of living-donor kidney transplantation.