Background: Working in the medical field is associated with extremely advanced levels of strain. Burnout is a prolonged reciprocation to the continuously persistent emotional and interpersonal stressors on the job and is clarified by the 3 dimensions of emotional exhaustion, depersonalization, and reduced personal accomplishment. Objectives: To evaluate the prevalence of burnout among residents at King Abdulaziz Medical City in Riyadh. Materials and Methods: A cross-sectional study was conducted on medical and surgical residents at King Abdulaziz Medical City in Riyadh. Data were collected through a previously validated questionnaire. Part 1 of the questionnaire was the demographic data collection sheet. Part 2 was the Maslach Burnout Inventory for Health Services Workers (MBIHSS). Results: The 60% of the respondents were male and the mean age was 28 years. Most respondents reported that they work for 51-60 hours per week (33.50%) and 27.50% of them work for 61-70 hours per week. Total 51% of the participants showed high depersonalization, 31.50% exhibited low personal achievements and 12.50% with high emotional exhaustion. Conclusion: The high rates of burnout among residents in KAMC-R were alarming. Efforts to identify at-risk population were warranted and interventions to prevent burnout like counseling and social skills training were encouraged.