Present cross sectional study was carried out with a view to evaluate the Carbamazepine risk for coronary heart disease. Lipid profile and Framingham point scores were studied in 60 Epilepsy patients on Carbamazepine. The epileptic patients were compared with age and sex matched 60 healthy controls. Framingham Point Scores were estimated by taking into consideration several parameters i.e. Age, Sex, Systolic blood pressure, HDL levels, Total cholesterol, and smoking history, as per guidelines of the Framingham Heart Study group We conclude that this drug significantly increases the risk for coronary heart disease in patients with respect to lipid profile and other parameters as described by the Framingham study group. Altogether, this drug may be one of the reasons for the high prevalence of CHD, which is increasing day-by-day due to the globalization.