Background: The metabolic syndrome (Met S) is composed of heart attack predisposing factors as diabetes, abdominal obesity, high cholesterol, and high blood pressure. Protein tyrosine phosphatase 1B (PTP1B), is negatively regulating the leptin and insulin signalling, with positive correlation with adiposity and contributes to insulin resistance. The effect of PTP1B on the obesity is still vague. This study aimed to study the association of PTPN1 polymorphism (467T>C) with Met S components and its metabolic compartments via examining the PTPN1 (467T>C) alleles and genotypes between Met S Egyptian patients and controls. Methods: Polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analyses were applied to investigate the 467T>C variants in 100 Egyptian Obese patients comparing to 80 controls. Results: No significant association was observed of 467T>C PTPN1 genotypes between patients and healthy Egyptians (X2=0.674, P=0.714). 467T> C PTPN1 variants displayed a non-significant correlation with Met S components. Conclusion: The PTPN1 promoter variant of 467T C was not associated with Met S components and T2DM metabolic related traits in type 2 diabetic Egyptian patients. More studies are required on a larger scale to examine any potential metabolic association.