High intra ocular pressure (IOP) often is related with open angle glaucoma. Although patients with high IOP are disposable to risk of open angle glaucoma, most of them never given it. In this study we evaluated association of hypertension and some other underlying causes with high IOP in population of patients referred to Amiralmomenin hospital during 2011-2012. This was a descriptive prospective study. Population was included patients with high IOP referred during 2012 to Amiralmomenin Hospital in Rasht. 180 patients with high IOP entered in the study. IOP of both eyes, systolic and diastolic blood pressure in admission were measured by expert assistant of ophthalmology and recorded. 55% of our patients were women. The mean age of them was 67.64±11.88 years. The mean systolic and diastolic blood pressure were respectively 128.66 ± 16.71 and 77.00 ± 9.02 mmHg. There was a significant relation between gender, history of hypertension, alcohol abuse, hyperlipidemia and cardiac disease with high IOP in right eye (p<0.05). Although there was a meaningful relation between changes of systolic blood pressure and IOP (p=0.005), there was no relation between changes of diastolic pressure and IOP (p>0.05). Our study showed that systolic blood pressure can predict the high IOP. The results indicate a high impact of intraocular pressure on measures of blood pressure in an Iranian sample population.