Objective: The Purpose of this systematic review was to evaluate the contemporary in vivo scientific evidence for resin infiltration (RI) in aesthetic and restorative dentistry. Materials and Methods: The PubMed database was searched for randomized controlled trials that evaluated the in vivo effect of RI as an adjuvant treatment in aesthetic and restorative dentistry and recent trends in this contest. The keywords used were ‘resin infiltration, recent trends’, ‘resin infiltration, aesthetic dentistry’, ‘resin infiltration, restorative dentistry’, with the ‘clinical trial’ filter activated. Among the 170 articles originally identified with these keywords, only 04 were included for this review. Results: All 4 articles reported on resin infiltration with respect to aesthetic and restorative dentistry. One of the studies had been conducted on 21 consecutive subjects with 39 quadrants in each group in which Resin infiltration improves the esthetic appearance of demineralized teeth. The results showed enough durability for over 6 months. The quality of the studies was assessed to be high with respect to simple randomization, controlled trial design. All the researches included showed color stability and improvement with respect to adjacent enamel surfaces after treatment with RI when compared with the baseline control group over a specific period. Conclusion: This systematic review revealed that RI appeared to be an effective method to improve an aesthetic and restorative outcome in terms of appearance and longevity of the restoration.