The use of animal models in scientific research is considered by many to be an absolute necessity, while some have questioned whether there are better alternatives. Nonetheless, animal models are currently a foundational piece of modern research practices. However, amongst the criticisms leveled at supporters of animal research, those which even supporters concede are necessary include sound methodology and design of such studies along with transparency for results. In Part 3 of a 3 Part series, a recently published safety assessment in mice administered a recreated OxyELITE Pro formulation is reviewed. Unfortunately, this study serves as yet another example where animal research has fallen short, suffering from numerous design and methodological issues and a lack of transparency in reporting results.