Sickle beta plus thalassemia (Hb S/β+ Th) is a rare inherited disorder among haemoglobinopathies. This disorder is inherited in an autosomal recessive manner. Sickle beta plus thalassemia patient usually have chronic haemolytic anaemia and rarely can present as vaso-occlusive painful crisis. Abdominal pain is frequently seen in vaso-occlusive painful crisis and may masquerade diseases such as acute appendicitis and cholecystitis. Acute pancreatitis is rarely included as a cause of abdominal pain in these patients. There are no systematic literature available which can give insight about this complication and its management. Here we report a case of sickle beta plus thalassemia presenting as acute pancreatitis.