Objective: To evaluate smoking pattern and associated factors related to smoking for patients attending anti-smoking clinic in Aseer region, Saudi Arabia. Methods: A Cross-sectional study design used to carry out this research using Arabic questionnaires to gather the data from anti-smoke clinics, Abha, Aseer region, KSA. The total 695 respondents included in this study and data were analyzed by using SPSS software. Results: The study revealed that majority of respondents attended anti-smoke clinics were educated (Secondary level 41.4% and university level 46.8%). Cigarette smoking (61.6%) was observed among patients and mostly was motivated to initiate smoking by friends (47.5%). Impulse to cessation of smoking was due to religious and health reasons both contributed 21.9%. And this study also showed that married respondents (56.1%) were more interested to participate in cessation trials than unmarried. Conclusion: There is an urgent need of equity based health intervention programs, tobacco control programs to be implemented effectively in order to provide counselling and guidance to quit smoking, training, capacity building and more anti-smoke clinics should be established.