Intensive Care Units (ICU) of hospitals have a dynamic environment in which physiotherapists play a great role and work along with the multidisciplinary team and provide great care in acute conditions and rehabilitation programs. Objective: The objective of the study was to find out the barriers to early mobility therapy that are perceived by the staff of ICU. Methods: The study design is cross-sectional comparative. The sample size of 138 medical staff (different Government hospitals) was divided into two groups. Group 1 was denoted as medical ICU staff and Group 2 was denoted as surgical ICU staff. A four-point Questionnaire was used to find the barriers to early mobilization in ICU practice. Results: The results of the study showed the significant difference of institutional barriers between surgical ICU (mean=6.25) and medical ICU (mean=4.30), the list of other barriers in surgical ICU (mean=4.92), and in medical ICU (mean=5.35) were significantly different. The barriers other barriers perceived by the medical ICU were high as compared to the surgical ICU. Whereas the list of patient-related barriers to early progressive mobilization in surgical (4.5) vs. medical (4.6) ICU were significantly having no statistical difference. Conclusion: It is concluded that the ICU staff perceived barriers to early progressive mobilization of patients slightly different in medical and surgical ICU.