Background: Oral cancer is most common in males and also in females. Betel quid (BQ) is the main causative agent of oral cancer. Areca catechu, a major component of BQ, contains certain alkaloids that give rise to nitrosamines. Mitotic index (MI) and Micronuclei (MN) were studied among the studied population. Methods: In this present study subjects were screened from Department of E.N.T. & Department of Oral and Facio maxillary of RKMSP hospital, and different areas of Eastern and North Eastern states of India. For mitotic index (MI) blood leukocyte cultures were analyzed and for micronuclei (MN) buccal mucosa were examined. Results: Some of them had more than one addiction. Micronuclei percentage and mitotic index both higher than normal. Conclusion: Betel quid play a role in changing the oral pathology and thus causes oral cancer.