Major depressive disease is one of the prevalent psychiatry diseases. Its effects on health of patients include desire to commit suicide and resistance to medical treatment. ECT is the most effective method of treatment in this regard. The objective of the study is to compare two anesthesia induction methods of thiopental Sodium and thiopental sodium- midazolam on ECT results in the major depressed patients. The study was conducted as clinical trial research. Sixty major depressed patients needed ECT by approval of psychiatrist were divided into two groups (each containing 30). One group was anaesthetized by thiopental sodium-midazolam, and the other group was anaesthetized by thiopental sodium. The therapeutic response, energy consumed, convulsion duration, and anesthesia and recovery time were evaluated. The independent t-test and Chi-square were used to analyze the data, and SPSS 21 software was used to analyze the output of results. The anesthesia period, recovery time, and Joule given to create convulsion were higher in thiopental sodium- midazolam group (13.70 minutes, 19.73 minutes, 67 Joules, respectively) compared to thiopental sodium group (9.23 minutes, 19.20 minutes, 63 Joules, respectively), but this difference was not statistically significant. The convulsion period in the thiopental sodium (26.03 minutes) group was higher than other group (21.06 minutes), but this difference was not significant (P=0.170). The results show that the reduced dozes of midazolam along with thiopental sodium not only prevent the probability of emergence from anesthesia reactions caused by thiopental sodium, but also leave the minimum effect on convulsion threshold.