Oral endotracheal intubation is a common method for airway maintenance and management in critical situations and is used for a variety of surgical procedures in operating rooms for airway management. This study aimed to investigate the effect of 2% lidocaine injection into endotracheal tube on the incidence of cough and laryngospasm after tracheal estuation during general anesthesia in patients undergoing eye surgery at Valiasr Hospital. This clinical trial was conducted on 96 patients older than 20 years of age undergoing eye surgery. After anesthesia with midazolam, thiopental, and atracurium, intubation was performed by a skilled person in both groups. The experimental group received 100 mg (5 CC) 2% lidocaine, kept at operation room temperature, instilled by a sterile syringe into the endotracheal tubea minute before reverse infusion to the patient, but the control group received no intervention. Five to ten minutes before the end of surgery, anesthetics were discontinued and after surgery, the endotracheal tube was removed. Then, the heart rate, the mean arterial pressure, the number of patient’s cough in three states and laryngospasm in five states were recorded. The findings showed that there was a significant difference in the frequency of cough on arrival to the recovery room between patients in the control and case groups (p=0.03), but no significant difference was observed between the frequency of coughing during estuation and leaving the recovery room. A significant difference was observed between the two groups (p<0.05) in terms of the heart rate on arrival to the recovery room and leaving the recovery room, and also in terms of the incidence of cough on arrival to the recovery room.