Scoliosis is a lateral curvature of the spine and it is a common cause of back pain especially myofacial pain. Cognitive functional therapy is a novel challenges pain-related behaviors in a cognitively integrated, functionally manner. To study the effect of cognitive functional therapy in treatment of back pain due to postural scoliosis. Thirty Egyptian female patients were assigned randomly in to two equal groups. Patients in the control group received traditional therapeutic exercises (myofacial release, stretching and strengthening exercises of the back muscles), while patients in the experimental group received the same program of control group in addition to cognitive functional therapy. Each group received the program three sessions/week for six weeks. The severity of pain, functional disability, cobb's angle, and lumbar range of motion (flexion, extension, side bending to convex side of scoliosis) were measured before and after 6 weeks of treatment. The statistical analysis revealed that there were there were significant reductions in pain level and functional disability and significant increase in ROM of trunk flexion and trunk extension and side bending between both groups (p < 0.05) in favor to study group. Conclusion: Supplementation of cognitive functional therapy in therapeutic exercise with myofacial release provided additional benefits with respect to pain, function disability, and lumbar range of motion (flexion, extension, and side bending) in patients with back pain due to postural scoliosis after six weeks of treatment.