Objective: This project aims to investigate the effect of curcumin-black pepper on the body fat composition and the lipid profiles of overweight adults. Methods: This randomized, placebo-controlled trial was conducted with 66 overweight males. Participants were randomly divided into two groups. Group A (32) received curcumin and black pepper dietary supplements. Group B (34) received a placebo. Results: Unlike the placebo, taking curcumin-black pepper resulted in significant improvements in High-Density Lipoprotein (HDL) (p<0.001) and significant reductions in body weight, Body Mass Index (BMI), Triglycerides (TG), Low-Density Lipoprotein (LDL), cholesterol, and fat composition (p<0.001) but not in visceral fat. Conclusions: A compound of curcumin-black pepper showed promising findings for improving lipid profiles, body weight, and body fat. This compound reduces body fat composition and serum lipids among overweight male adults. Further studies may be required to clarify the mechanism and effects of this compound on other physiological aspects.