Today improve lifestyle and health promotion is a basic requirement for human society and the need for more tangible factor in the increase in chronic diseases such as chronic kidney disease and hemodialysis process is followed. As life expectancy increases, due to the importance of promoting behavior change. The aim of this study was to evaluate the effect of health promoting behaviors was on the lifestyle of patients undergoing hemodialysis. In this study, 70 patients undergoing hemodialysis training centers - medical Hamadan were selected. That is because Hamedan only two dialysis centers, randomly one of them was selected as a test group and a control group. Of the patients referred to the center for sampling in each group 35 patients were studied. For groups of six 30-minute sessions on an individual basis during hemodialysis, held over three weeks in a row. Data analysis using descriptive statistics and statistical tests of Kolmogorov - Smirnov, T and T were analyzed with SPSS version 16. In the experimental group, health-promoting lifestyle scores before and after intervention showed significant statistical differences (001 / 0 < p). The mean scores of health-promoting lifestyle intervention and control groups after the intervention, there was a significant difference (p<0.05). Teaching with an emphasis on health-promoting behaviors, hemodialysis patients was improved lifestyle. Develop and implement training programs to improve lifestyle behaviors and health promoting effective step is hemodialysis patients.