Chemerin is a pro-inflammatory cytokine that is newly discovered and plays an important biological role in fat tissue formation. The aim of this study was to investigate the effect of eight weeks of resistance training on serum levels of Chemerin and body composition in overweight men with disabilities. This study was quasi-experimental with pre-test, post-test, and a control group. Twenty disables people from Zahedan aged 25±3 and body mass index (BMI) 25±2 kilograms per square meter were purposefully selected and randomly assigned into control (n=10) and control (n=10) groups. The experimental group started to exercise in a circuit resistance training for eight weeks, each week three sessions with 60 to 65% intensity, and 1 maximum repetition and finished it with a gradual increase to 70 to 80% one maximum repetition in final sessions. Before and after training, chemerin values and anthropometric indices were calculated. Kolmogorov-Smirnov test was used for testing the normality of data distribution. Parametric paired t-test was used to study variables changes within a group. Moreover, independent ttest at the significant level α<0.05 was used to study the significance of inter-group differences in the changes in pre-test and post-test of experimental and control groups, and they were analyzed with SPSS software. Intragroup changes showed that eight weeks of resistance training has had significant effects on decreasing chemerin level, body weight, BMI, body fat percentage, and waist-to-hip ratio (p<0.05). Moreover, in inter-group changes, a significant decrease was observed in waist-to-hip ratio (p<0.05). In other variables, differences in changes between the experimental group compared to the control group were not significant (p>0.05). Eight weeks of resistancetraining for the experimental group compared with the control group has no effect on the chemerin level and body composition of the overweight people with disabilities. It seems that these exercises should be performed for longer duration and with more intensity for effective utilization of resistance training.