International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Abstract
The Effect of Gayo Arabica Coffee Leaf Extract on Blood Sugar Levels in Rat with Type 2 Diabetes Mellitus
Author(s):Sake Juli Martina* and Inda YohanaPurpose: To understand the effect of ethanol extract of Gayo Arabica coffee leaf (Coffea arabica) on changes in blood glucose levels in type-2 diabetes mellitus rats (Rattus norvegicus). Research Methodology: To understand the effect of ethanol extract of Gayo Arabica coffee leaf (Coffea arabica) on changes in blood glucose levels in type-2 diabetes mellitus rats (Rattus norvegicus). Results: The study showed a decrease in blood glucose levels which was significant with a value of p=0.035 after giving Gayo Arabica extract 150 mg/kg/day to rats for 13 days. Limitations: This research provides treatment for 13 days. Contribution: Gayo Arabica coffee leaves show had chlorogenic acid which can stimulate glucose uptake in skeletal muscles with AMPK activity, which leads to a decrease in glucose levels in the blood. This supports Gayo Arabica coffee leaves as a good anti-diabetic for type 2 diabetes mellitus.
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