Background: Inhalation anesthesia using Isoflurane in pediatrics is related to airway irritability, coughing, breath holding, and laryngeal spasm. This study aims to determine the effect of i.v. Lidocaine 5 minutes before emergence on the incidence and severity of postoperative respiratory complications of Isoflurane in a pediatric population. Method: A randomized clinical trial study conducted in Children Welfare Hospital included 118 unpremeditated children, aged 6 months to 10 years who were enrolled in the study and randomized to receive iv. Lidocaine (n=54, Group A) and Not receiving Lidocaine (n=64, Group B). Were all induced with Propofol and maintained with Isoflurane. The occurrence of coughing, breath-holding, laryngospasm, bronchospasm, and secretion was recorded. The severity of each complication was graded on a scale of 0-3. Results: The incidence of coughing (31% vs 56%) and laryngospasm (22% vs 59%), coughing severity score (26 vs 72), breath-holding severity score (16 vs 38), and the need to change to a higher FiO2 (4% vs 11%) were more frequent in Group A than in Group B (p<0.05). There was no difference regarding the incidence of breath-holding (26% vs 31%) and secretion (30% vs 31%). Conclusions: i.v. Lidocaine 5 minutes before emergence from anesthesia reduces the frequency and severity of coughing, the frequency of laryngospasm, the severity of breath-holding, and the need to change to higher FiO2 in pediatrics.
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