The aim of the present research is to determine the effect of logo therapy on life orientation of cancer patients. The research method was quasi-experimental with control group and testing. Statistical population includes all cancer patients about 220 persons under support of Yas association of Kerman in 2013. The sample of research consisted of 15 persons in control group and15 persons in experimental group. Randomly sampling is used for sampling method. Scheier and Carver's 1985 Life Orientation questionnaire was used for collecting data. Data analysis was done by Spss20 software and covariance analysis. The findings showed that group logo therapy has a positive and significant impact on optimistic orientation in life and control of cancer patient’s emotions. Persons in charge of health, medical and welfare of country must try to explain the importance of give meaning to life of patients through broadcasting for citizens by counselors and top psychologists in order to reduce psychological disorders and subsequently to recover the cancer patients.