Objective: This study is aimed to assessment the relationship between sexual satisfaction and quality of life(QQL) in patients with cardiovascular disease at the city of Ilam. Background: Heart disease is a leading cause of mortality and reduced quality of life(QQL). Lack of sexual satisfaction reduces health, longevity and life satisfaction, and also leads to disorders in the growth and development of couples and their sexual relationship. Method: In this crosssectional study 300 cardiovascular patients at Ilam were selected by using convenience sampling method. The instrument used was Larson sexual satisfaction questionnaire and 36- SF quality of life survey. Data were analyzed using spss21 as well as descriptive statistics (mean and standard deviation) and inferential statistics (t-test and ANOVA). Ethical considerations: moral considerations in this study include obtaining the permission of hospital officials to conduct the study, explaining the purpose and methodology of the study for each of the subjects; informed consent was also obtained from each subject for research. Findings: Results showed that the mean and standard deviation of the quality of life and sexual satisfaction are 59.17± 22.53 and 49.15± 6.03, respectively. The highest score of the quality of life of heart disease was related to public health and the lowest score belonged to physical pain. Pearson correlation test showed a significant relationship between quality of life and sexual satisfaction. Also, patients with hypertension had the greatest sexual satisfaction and it was lowest in patients with myocardial infarction. Conclusion: Necessary interventions to increase sexual satisfaction in cardiovascular patients can increase the quality of their life.