Logo

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)

Abstract

The Effectiveness of Ambon Banana Peel Extract (Musa sapientum) as Atherosclerosis Prevention through Inhibition of NF-κβ and Increased eNOS Expression in Atherogenic Rat Model

Author(s): Arlinda Silva Prameswar, Kartika Puji Rahayu, Eria Nahrani Pranadita, Dyah Puspa Ardani and Wafiyah Hasana

Atherosclerosis is a disease in which plaque builds up inside the arteries. During the early phase, endothelial nitric oxide nitrate (eNOS) decrease and nuclear factor kappa beta (NF-κβ) increase. Ambon banana peel contains XJP-1 and flavonoid which has been shown to inhibit the translocation of NF-κβ and increase eNOS expression in endothelial cells. This study was designed to investigate the effectiveness of Ambon Banana peel as atherosclerosis preventive agent through the inhibition of NF-κB and increasing eNOS expression in atherogenic rats. This study was post-test only control group design for 14 days using 30 male Wistar rats, divided into 5 groups: negative control with normal diet, positive control with atherogenic diet, and three control groups with atherogenic diet + 200 mg/kg body weight/ day, 400 mg/kg body weight/day, and 800 mg/kg body weight/day extract dosage. On the 15th day, the rats were terminated, taken its abdominal aortic and analyzed using immunohistochemical method. Statistical analysis showed that the extract significantly decreases NF-κβ (p=0.00) and increase eNOS (p=0.00). Pearson correlation proves that higher dose can lower NF-κ NF-κβ activity and increase eNOS expression (p<0.05). Linear regression shows that the extract can 82.1% lower NF-κβ activity and increase eNOS expression for 95.2%. In conclusion, the extract of Ambon banana peel has been proven to be effective in preventing atherosclerosis.


Card image
Subscribe Now!
Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology