The present article aimed to investigate the effectiveness of cognitive behavioral therapy in self-dissociation, sexual intimacy and alexithymia among married women. This research was a semi-experimental study (pretest-posttest design with unequal control group). The target population included all the married women who referred to psychological services clinics in Mashhad. The research sample comprised 30 of these married women (15 people in the experimental group and 15 people in the control group) who were selected voluntarily and through available sampling method. For data collection, Self-Dissociation Questionnaire by Oppenheimer and Estrogel (1999), Halbert Sexual Desire Inventory (1992) and Toronto Alexithymia Scale were used. To analyze the data, analysis of covariance (ANCOVA) was applied. The results obtained from data analysis demonstrated that cognitive behavioral therapy leads to reduced self-dissociation and alexithymia and increased sexual intimacy among married women in the experimental group compared to the control group (P<0.05).