Background and objectives: Background: Electronic cigarettes are a relatively new form of nicotine delivery devices that have quickly taken over the globe, and the long-term effects of e-cigarettes are still being evaluated. With the recent legalization of vapes and other forms of e-cigarettes in the United Arab Emirates (UAE), the consumers base significantly increased in the region, thus raising many questions for researcher to ask and evaluate. This cross-sectional epidemiological study hypothesizes that e-cigarettes have a negative effect on the health and safety of those who live in Abu Dhabi, UAE. The objectives of this study is to understand the health and safety risks associated with vaping/ smoking E-cigarettes, to measure the strength of association between E-cigarette derived nicotine and change in health status and to find the prevalence of people who have experienced any safety hazards while using e-cigarettes in the UAE. methods: Data collected from this paper rely on quantitative methods through self-administered surveys conducted using google docs.. Results: The data analyzed from the survey distributed around E-cigarette smokers in Abu Dhabi showed that the prevalence of people who experienced safety hazards while smoking e-cigarettes is 27.9%. The results also showed that the there is a positive (0.866) and significant (p < 0.001) correlation between nicotine concentration and health changes. Conclusion: The evidence and data analyzed from this cross-sectional study indicated that there is a negative effect on the health and safety of E-cigarettes smokers in Abu Dhabi, UAE.
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