Background: Evaluate the shear bond strength (SBS) and adhesive remnant index (ARI) after incorporation (1%) of silver, zinc oxide, or titanium dioxide nanoparticles to an orthodontic bonding agent. Materials and methods: Total 48 samples were selected and randomly divided into 4 equal groups (the 1st group was the control, while 2nd, 3rd and 4th were the test groups), containing 12 teeth each, according to the type of the nanoparticles (Ag, ZnO, or TiO2 nanoparticles) which are incorporated to the orthodontic bonding agent (Transbond XT primer). Bond strength was measured using an Instron machine at a cross-head speed of 1 mm/min, and then the enamel surface of each tooth was inspected under a stereomicroscope (10X magnification). Results: There were no significant differences between all groups, ANOVA F-test was used to measure the mean shear bond strength for control, Ag, ZnO, or TiO2 groups were 18.017, 16.921, 18.343, and 17.925 MPa respectively. Furthermore, chi-square test for adhesive remnant index showed highly significant differences between control and ZnO, and control and TiO2, while significant differences between control and Ag, Ag and TiO2, and ZnO and TiO2, while a non-significant difference between Ag and ZnO. Conclusion: The incorporating of silver, zinc oxide, or titanium dioxide nanoparticles into orthodontic bonding agent at concentration of 1% has no effect on shear bond strength, on the other hand, in regard to ARI, a considerably more adhesive remains on the enamel surface following bracket removal in the test groups than the control group, and this will reduce the enamel damage after debonding.