Background: Changes in lifestyle like displacing place could cause depression which is a common mental disorder that changes general health including growth that affects tooth alignment. However, one of the growth biomarkers is a growth hormone that is secreted in saliva. The aim of this study was to assess the relation of depression status on teeth alignment in relation to salivary growth hormone secretion among internally displaced people. Materials and methods: The sample includes 121 internally displaced people aged from 13-17 years. Method for depression is measured by using children depression inventory (CDI2) questionnaire. The total sample was assessed for tooth alignment using the criteria of the World Health Organization of 1997. The unstimulated salivary sample was collected from 60 persons under standardized condition then analyzed for assessment of human salivary growth hormone. Results: Reported that the presence of crowding in one arch was higher among person with a low grade of depression while crowding in both arch was higher in high depression grade than low grade. For the spacing score, the spacing in one and both arches was higher in high depression grade than low grade. Concerning salivary growth hormone, the data of the present study revealed no significant difference between a low and high grade of depression. Conclusion: Depression among internally displaced people had an effect on teeth alignment that couldn’t be screened by salivary growth hormone.