Aim: To understand and describe how the growth and development of slums in Guwahati, Assam influence the living conditions affect the health status of slum dwellers. Methods: A comprehensive literature review of 44 articles published during 1993 to 2016 in various databases computerized databases, hand searches, and authoritative texts was undertaken to reveal the inter-disciplinary character of the topic. The inclusion criteria for this study were to select items having scientific quality and were aligned with the objective of the study. Items were excluded if they were irrelevant to the slum areas, redundant and lacked scientific quality. Results: It is equally necessary to make sure that the health policies consider the importance of equity and social justice in slum areas. The nutritional condition of school going slum children and prevalence of diarrhea are issues to be taken care of. It was noted that the level of health awareness in Assam was less compared to the national level and the slum dwellers didn’t know how to avail these healthcare facilities. This was a barrier in improving their health status. Conclusion: We should nurture the aim to create a slum free society by providing proper housing, sanitation, safe drinking water, and affordable healthcare services. Special focus on the nutritional condition of slum children; maternal and child health in the slum areas of Assam is urgently required. Health and education must go hand in hand to uplift the lives of these slum dwellers.