Oral plaque is one of the most common oral lesions that occur in the form of recurrent ulcers. Various factors are effective in the etiology of oral plague, including immune disorders, blood defects, and mental stress. Various methods are recommended to treat these lesions, including the use of steroids. In this study, a type of mucosal adhesive was introduced that was examined alone as well as a steroid carrier for the treatment of aphthous ulcers. Aim: The purpose of the studies in this piece of research work is to focus on mucosal bioadhesive on oral aphthous ulcer pain how it affected the human body and it will give information to research scholars, doctors, and the public to explore their knowledge. Materials and Methods: This study was an experimental and double-blind study with simple random sampling. Two groups were studied: the first group (pre-test), including 20 people, who received drug-free adhesive to determine the degree of adhesion and other side effects of mucosal adhesive. The second group, including 20 people, was selected as case and control with a history of minor aphthous ulcer and during two periods of aphthous ulcer, once treated with drug-free mucosal adhesive (control) and again with drug-containing mucosal adhesive (case) was located. Statistical analysis was performed using a student t-test. Results: In the pre-test group, the duration of adhesion in all subjects was at least 20 minutes, and no specific taste or odor, or side effects, not reported. In the case and control groups, the time to analgesia and the time to complete recovery were almost the same. Recovery time was shorter after treatment than in pre-treatment patients. Conclusion: Since aphthous ulcer pain is usually due to secondary infection or mechanical and chemical irritation, the use of mucous adhesive as a covering and protective material can cause analgesia and accelerate the healing time. Mouth sores. The presence or absence of triamcinolone in the mucosal adhesive also affects reducing pain and accelerating the duration. There is no healing of aphthous ulcers.