Introduction: Gender roles as performed by individuals are based on the different social expectations on the basis of sex, values, and beliefs. These roles are arranged along masculinity (men) and feminine (women) lines. Materials and methods: A cross-sectional descriptive study design among men in the Tamale Metropolis was conducted. Total 30 clusters (communities) were selected in the metropolis using the probability proportional to their size. The second stage involves the use of EPI random walk method to select 19 men each from 10 communities and 20 men from 20 communities. Results: The socio-demographic characteristics of the respondents showed that 37.3% of them were living in urban areas within the Tamale metropolis whilst 29.5% were living in rural areas and 33.2% were living in peri-urban. The mean age of the respondents was 26.3 ± 4.1 years. Conclusion: There was a widespread use of sex enhancement drugs among men in the Tamale metropolis. There is a need for public education/enlightenment by government and advocacy groups to address the problems of ignorance and stigmatization associated with erectile dysfunction.