Objective: Rhizarthrosis indicates osteoarthritis induced degenerative changes of the thumb root. Several surgical interventions have been previously described. Our question is whether the PyroSphere joint replacement shows superior results when compared to other operative techniques such as Epping-Plasty for the treatment of thumb root arthritis. Therefore, the purpose of this study was to compare the efficacy of both interventions. Methods: In this clinical cohort study we reviewed our medical database to identify patients who suffered from rhizarthrosis Grade II-III according to Eaton Littler, who were treated operatively between 2002 and 2018. After a mean follow-up of 13 years, 14 cases were evaluated. Evaluation by clinical examination includes range of motion of the thumb, Kapandji score, force measurement of the thumb and hand using JAMAR dynamometer for grip and pinch strength. Pain assessment was done; DASH-Score and DSG questionnaire were also performed. Results: 14 hands were included, The PyroSphere joint prosthetics were observed in 7 hands and the Epping-Plasty group included the other 7 hands. In all comparative tests, P values were not statistically significant (all p>0.05). Conclusion: This study concludes that PyroSphere prosthetics show no superior results when compared to Epping-arthroplasty for the treatment of thumb root arthritis.