This study aimed to identify the relationship between perceived stress and coping styles with psychological wellbeing in cardiac patients. The study population consisted of all cardiac patients in the Shahid Rajaei Tehran hospital have to record. The statistical sample to a form of available and with the full consent 170 people was selected. Research tools were Cauldron stress questionnaire, Ryff psychological well-being (1989) questionnaire and coping skills by Lazarus & Folkman (1982). To analyze the data inferential statistical indicators was used multiple regression and Pearson correlation coefficient. The results showed that: need the approval of others, high expectations of themselves, high concern along with anxiety, dependence, and helplessness to change themselves, contribute in predicting of psychological well-being. As well as there is a correlation between perceived stress with management and decision on working pressure, mental health and stress due to life and stress due to the character. There is an inverse correlation between problem-focused coping styles with perceived stress. It was also shown that predictive perceived stress factors contribute in predicting psychological well-being. Based on the results suggest by teaching effective coping strategies and stress reduction strategies be provided greater psychological well-being for cardiac patients.