The aim of this study was to investigate the role of life skills and self-efficacy in mental health secondary school students in Ardabil in the 2014-2015 school years. Research In terms of purpose, was functional and in terms of method was correlational. The population of this research was the secondary school students in Ardabil, with the number of 4067 people. For sampling, stratified random sampling method was used and the sample size of 351 patients was selected based on Morgan table. To collect data for statistical sampling the questionnaire (selfeducation (Oven and Franman, 1998), general health (Goldberg and Hiller (1979) and life skills (Saatchi et al., 2010) was used and for data analysis, descriptive and inferential statistical methods were used. The results of this study showed that mental health, self-efficacy and life skills of students are in a satisfactory condition. The results showed that there is positive direct relationship between mental health and life skills and components of life skills and mental health and self-efficacy of students. The results show that the factor of skill related to interpersonal relations have predicted variable of life skills and this component has explained 0/030% of changes in the mental health of students.